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Cancer Evolution

DFG: SFB 1243 - Integrated Research Training Group

The Collaborative Research Center SFB 1243 "Cancer Evolution. Genetic and Epigenetic Evolution of Hematopoietic Neoplasms" studies different aspects of cancer development in an evolutionary framework, in particular the grounds for the poor prognosis of acute myeloid leukemia and indolent lymphomas. Using interdisciplinary approaches, the projects aim to decipher molecular mechanisms, measure the evolution of genetic, epigenetic and transcriptional heterogeneity in patients, mice and cellular systems, and to quantify relevant parameters by applying computational models.
The Integrated Research Training Group offers training in state-of-the-art techniques, including genetic engineering, single cell genomics, next-generation sequencing and computational data analysis. Research projects are supervised collaboratively by clinicians, molecular biologists, population geneticists, computational and evolutionary biologists. Doctoral researchers are encouraged to develop networking and communication skills necessary for successful careers in science.